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Generic Motilium is utilized to supress sickness and sickness, and works primarily by blocking dopamine receptors based in the top end of the digestive system. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the way that is wrong the stomach and so prevents reflux (regurgitation of the stomach contents right back into the foodpipe).

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Since domperidone is highly metabolised in the liver, domperidone should be used with caution in patients with hepatic disability (and in the elderly).

Domperidone must be used with caution in clients with renal disability or in those at threat of fluid retention. In patients with severe renal insufficiency (serum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should once be reduced to or twice daily, depending on the severity of impairment, and the dose may require to be reduced. Patients on prolonged therapy should regularly be reviewed.

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